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KMID : 0882419770200070597
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Korean Journal of Medicine
1977 Volume.20 No. 7 p.597 ~ p.601
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Inhibitory Effect of a Rodenticide RH-787 on the Glucose Metabolism of Erythrocytes
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Lee Tae-Hee
Lee Min-Wha
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Abstract
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In an attempt to clarify the mechanisms for the hyperglycemic effect of a rodenticide RH-787 (N-3pyridylmethyl-N´-p-nitrophenylurea), effects of the rodenticide on the uptake of methylene blue and glucose consumption by erythreocytes were studied in vitro and in vivo. The uptake of methylene blue by erythrocyte, which is dependent on glucose metabolism through the pentose phosphate pathway, was depressed 1020% by 1.0 mM RH-787 added in vitro to human and rabbit erythrocytes. This inhibitory effect of the` rodenticide was accentuated by the prior treatment of human erythrocytes with RH-787. The erythrocytes from RH-787-poisoned patients showed a markedly depressed glucose consumption as well as a decreased uptake of methylene blue in the presence of glucose. These results indicate that RH-787 exerts a direct inhibitory effect on the glucose metabolism of erythrocytes. Possible mechanisms for this inhibitory effect were also discussed.
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